Aim: In this study, it was aimed to examine the relationship between serum levels of neopterin, which is considered a marker of cellular immunity and oxidative stress, and the presence of H. pylori, which causes both inflammation and increased oxidative stress.

Material and Methods: Fifty-three patients with chronic gastritis and 14 healthy volunteers were included in the study. According to the histopathological examination results, patients with chronic gastritis were divided into two groups as H. pylori positive (n=24) and H. pylori negative (n=29). Neopterin measurements were performed on HPLC device. Whether serum neopterin levels differed between groups and whether neopterin and H. pylori quantity, degree of inflammation and activity were correlated, were analyzed by appropriate statistical methods.

Results: Although the serum neopterin level was higher in the H. pylori positive chronic gastritis group, there was no statistically significant difference between the groups (P=0.369). No correlation was found between serum neopterin levels and H. pylori quantity, degree and activity of inflammation (P>0.05).

Conclusion: Serum neopterin levels are unchanged in patients with chronic gastritis with H. Pylori positive or negative compared to healthy controls. It was thought that neopterin levels could not be used as a marker of H. pylori positivity or chronic gastritis.