Aim: A number of recent reports have investigated the origin of false-positive hCG results. This case report demonstrates a slightly high true positive hCG in a young female patient with chronic kidney disease.

Materials and Methods: The patient’s serum hCG value was measured with 4 immunoassay systems. Dilution and (polyethylene glycol) PEG 6000 precipitation were performed.

Results: hCG results were found slightly high in the 4 immunoassay method. The recovery ratio was calculated as 0,98 for the dilution result and 0,54 for PEG result on Immulite. Dilution and PEG 6000 precipitation studies were not supported heterophile antibody presence.

Conclusion: Further work-up showed that the unexpected positive hCG result was secondary to Chronic Kidney Disease (CKD). It should be considered that HCG may be elevated in CKD patients like our case.