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2020, Cilt 18, Sayı 3, Sayfa(lar) 136-143
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Elevation of NT-pro-BNP levels in high fever patients without heart failure
Hacer Koç1, Özlem Çakır Madenci2, Asuman Orçun2, Nihal Yücel2, Şeymanur Sağlam3, Nurdan Papila Topal4
1Muş State Hospital, Biochemistry Laboratory, Muş, Türkiye
2Kartal Dr Lütfi Kırdar City Hospital, Biochemistry Laboratory, İstanbul, Türkiye
3Kartal Dr Lütfi Kırdar City Hospital, Department of Infectious Disease, İstanbul, Türkiye
4Kartal Dr Lütfi Kırdar City Hospital, Department of Cardiology, İstanbul, Türkiye
Keywords: CRP, Fever, NT-proBNP, Procalcitonin, Heart failure
Abstract
Objective: We aimed to investigate the NT-proBNP levels in high fever patients without heart failure, to contribute to the proper request and interpretation of the test.

Methods: Patients group included 31 patients who admitted with a body temperature ≥38ºC and showed no signs of heart failure on their echocardiograms. Patients were internalized in the Infectious Diseases Clinic. The control group included 31 healthy subjects. NT-pro-BNP, Procalcitonin (Cobas e 601 Roche Diagnostics, Germany), Complete Blood Count (Beckman Coulter LH 780, USA) and CRP (Siemens BN II Nephelometer, Germany) levels were evaluated.

Results: Median (2.5-97.5 % percentiles) body temperature values of the patients and controls were 38.4 (38.0 - 39.8) and 36.1 (36-36.6) C° respectively (p < 0.0001). Median (2.5-97.5 % percentiles) NTproBNP levels of the patients and control groups were; 240 (48.3- 2637) and 34.8 (5.35-86) ng/L respectively (p < 0.0001). NT-proBNP levels correlated significantly with body temperature, CRP, and PCT ( r=0.761, 0.726 and 0.727 respectively, all p’s < 0.0001). We observed recovery at 8 patients (at least 48 hours without fever), and median (2.5-97.5 % percentiles) NT-proBNP levels at time of fever and without fever were 378.3 ( 80.2- 1642) and 183 (9- 419.8) ng/L, respectively ( p=0.007). In multiple regression analyses; body temperature, leucocyte count and PCT were found predictive for NT-proBNP levels. (R²=0,456, F=11.987, P<0,001)

Conclusion: Despite to the normal cardiac functions, elevated NT- proBNP levels are observed in patients with fever. This situation should be considered in the interpretation of high NT- proBNP levels.

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