Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2020, Cilt 18, Sayı 3, Sayfa(lar) 121-128
[ Özet ] [ PDF ] [ Benzer Makaleler ] [ Yazara E-Posta ] [ Editöre E-Posta ]
A Prospective Evaluation of Vascular Calcification Markers in Renal Transplantation
Bilge Karatoy Erdem1, Vural Taner Yılmaz2, Gültekin Süleymanlar2, Ayhan Dinckan3, Halide Akbas1
1Akdeniz Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Antalya, Türkiye
2Akdeniz Üniversitesi Tıp Fakültesi, Nefroloji Bilim Dalı, Antalya, Türkiye
3Akdeniz Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Antalya, Türkiye
Keywords: renal transplant, vascular calcification, biomarkers, Fetuin A, PPi
Abstract
Aim: The evaluation of biomarkers linked with inhibition and activation of vascular calcification in pre and post renal transplant period in renal transplant recipients was aimed in this research.

Patients and Methods: 35 recipients who had undergone living-donor kidney transplantation were included. Plasma 1,25-dihydroxyvitamin D3, serum 25-hydroxyvitamin D3, calcium, phosphorus, inorganic pyrophosphate (PPi), osteoprotegerin (OPG), alpha-2 heremans-schmid glycoprotein (Fetuin- A), alkaline phosphatase (ALP), bone morphogenic protein-2 (BMP-2), creatinine, parathyroid hormone (PTH) levels were analyzed immediately before and 6 months after transplantation. Statistical analysis was done using SPSS version 20.0.

Results: This research reported that vitamin D deficiency continues independently of renal function in renal transplant recipients. Despite the low levels of vitamin D, its active form was increased with the improvement of renal function. It also observed that PPi and Fetuin-A levels increase, OPG and ALP levels decrease with the improvement of graft function.

Conclusion: Serum biomarkers could serve as important indicators of vascular calcification in renal transplant recipients. The increase in serum levels of OPG and ALP, which are thought to play a role as activators in the calcification process in patients with Chronic Kidney Disease may be beneficial in early detection of calcification. Further larger studies are required to evaluate time-dependent changes after renal transplantation.

  • Top
  • Abstract
  • [ Başa Dön ] [ Özet ] [ PDF ] [ Benzer Makaleler ] [ Yazara E-Posta ] [ Editöre E-Posta ]
    Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim