Objective: In this study we aimed to calculate the median levels of free β-hCG and PAPP-A levels of pregnant women in our area and to search the relationship between the pregnancy complications and these medians.

Material and Methods: The serum free β-hCG and PAPP-A levels, nuchal translucency and crown rump lengths were measured in 314 pregnant women who applied for routine pregnancy monitoring. The risk was calculated using the Prisca 4.0 software. The chorion villus sampling of the pregnants with high risk was performed and sent for karyotype analysis.

Results: High risks of Down syndrome were determined in 7 of the 314 pregnants but their chorion villus sampling was normal. Differences in median levels of free β-hCG and PAPP-A between ours and Prisca 4.0 programÕs were determined. 57 pregnants who gave birth were divided in three groups; intrauterin growth retardation, preterm and normal. Pregnants with intrauterin growth retardation had significantly lower free β-hCG MoM levels compared with the other two groups (p=0.024). But there was no statistically significant difference between preterm and normal groups regarding to free β-hCG MoM levels. We also did not determine significant differences in PAPP-A results between groups.

Conclusions: In the first trimester screening test we think using medians which are for their own population are most suitable than using the medians of which are use in the software. The usage of free β-hCG levels in early stages of pregnancy may be helpful in monitoring the pregnants with the risk of intrauterin growth retardation.