| 2022, Cilt 20, Sayı 1, Sayfa(lar) 054-062 |
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Change of Lipid Profile and Oxidative Stress Markers with Treatment in Hypogonad Patients |
Kenan Güçlü1, Fahri Bayram2, Gülden Başkol3, Osman Başpınar4, Aydoğan Aydoğdu5 |
1Ahi Evran University Faculty of Medicine, Department of Biochemistry, Kırşehir, Türkiye
2Erciyes University Faculty of Medicine, Department of Endocrinology and Metabolism, Kayseri, Türkiye
3Erciyes University Faculty of Medicine, Department of Biochemistry, Kayseri, Türkiye
4Kayseri Training and Research Hospital, Department of Internal Medicine, Kayseri, Türkiye
5Gülhane Training and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Türkiye |
Keywords: Hypogonadism, oxidative stress, gonadotropin |
Aim: To investigate the presence of oxidative stress and dyslipidemia, which increase cardiovascular
risk, and the effect of gonadotropin replacement therapy on these parameters in patients with
Idiopathic Hypogonadotropic Hypogonadism (IHH).
Material and Methods: This was a phase IV, non-randomized, case-controlled study. Male patients
diagnosed with IHH (n=30), and a control group of healthy participants with similar age and body mass
index (BMI) (n=20) were included. Oxidative stress markers, lipids and apolipoprotein levels were
measured before and after gonadotropin treatment and compared with healthy controls.
Results: After treatment, a dramatic decrease was observed in high-density lipoprotein (HDL), lowdensity
lipoprotein (LDL), advanced oxidation protein products (AOPP), malondialdehyde (MDA) and
nitric oxide (NO) levels, while a significant increase in thiol level was detected (p<0.05).
Conclusion: The data obtained indicated the presence of dyslipidemia and an increase in oxidative
stress in hypogonadism cases, and showed that gonadotropin treatment reduced the oxidative stress of
patients and positively affected their lipid profile.
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