Aim: During pregnancy, metabolic and oxidative changes are seen, including various trace elements and oxidative stress. The main purpose of this study was to evaluate zinc, copper concentrations and oxidative status compared to trimesters in normal pregnancy.

Material and Methods: 30 (T1) in the 1st Trimester, 30 (T2) in the 2nd Trimester, 30 (T3) in the 3rd Trimester and 30 non-pregnant women (Control) in the same age group were included in the study. Serum Zinc, Copper, MDA, GPX and Catalase levels were evaluated from all individuals.

Results: Zinc and copper continued to increase until the third trimester of pregnancy, where a slight decrease was observed. (respectively, p = 0.000 and p = 0.003). While there were irregular changes in MDA in every trimester, no significant change was observed in the control and trimesters in GPX. In the catalase levels, although the pregnancy trimester was higher in the control group, the level of Catalase increased as the pregnancy trimester progressed.

Conclusion: The profiles of trace elements in different trimesters in pregnant women varied. A single measurement of trace elements in serum does not seem sufficient to describe their levels during pregnancy.