2020, Cilt 18, Sayı 3, Sayfa(lar) 144-149 |
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Ischemia-modified albumin as a Predictor of the Disease Activity in Rheumatoid Arthritis |
Ayfer Çolak1, Filiz Meryem Sertpoyraz2, Anıl Baysol1, Elif Merve Girgin1, Ali Taylan3 |
1SBÜ Tepecik Eğitim ve Araştırma Hastanesi, Biyokimya, İzmir, Türkiye 2SBÜ Tepecik Eğitim ve Araştırma Hastanesi, Fiziksel Tıp ve Rehabilitasyon, İzmir, Türkiye 3SBÜ Tepecik Eğitim ve Araştırma Hastanesi, Romatoloji, İzmir, Türkiye |
Keywords: Disease activity score, Ischemia modified albumin, Rheumatoid arthritis |
Purpose: Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease characterized by
synovial inflammation, cartilage damage and bone erosion. Ischemia modified albumin (IMA) is a
potential marker that can be used to assess atherosclerosis-related myocardial ischemia.
Cardiovascular events such as myocardial infarction and stroke are common diseases in rheumatic
diseases. We aimed to evaluate the relationship between disease activity and ischemia modified
albumin level and ischemia modified albumin / albumin ratio (IMAO) in patients with rheumatoid
arthritis.
Material and Methods: This study included 72 rheumatoid arthritis patients and 72 healthy controls.
Disease activity was evaluated with the disease activity score (DAS28). Serum ischemia-modified
albumin concentration was measured spectrophotometrically using the albumin cobalt binding test.
Results: The mean ischemia-modified albumin concentrations in rheumatoid arthritis group and
healthy controls were 0.46 ± 0.16 ABSU and 0.39 ± 0.10 ABSU, respectively, and the difference was
statistically significant (P = 0.002). Serum ischemia-modified albumin levels were found to be positively
correlated with Disease Activity Score of 28 joints (DAS28), serum ischemia modified albumin / albumin
ratio and serum C-reactive protein (CRP) level (r = 0.419, r = 0.594, r = 0.648, respectively,).
Conclusion: Higher levels of ischemia-modified albumin in patients with rheumatoid arthritis or in
those with active disease suggest that it may be associated with pathogenesis and activity of the
disease.
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