2020, Cilt 18, Sayı 3, Sayfa(lar) 136-143 |
|
Elevation of NT-pro-BNP levels in high fever patients without heart failure |
Hacer Koç1, Özlem Çakır Madenci2, Asuman Orçun2, Nihal Yücel2, Şeymanur Sağlam3, Nurdan Papila Topal4 |
1Muş State Hospital, Biochemistry Laboratory, Muş, Türkiye 2Kartal Dr Lütfi Kırdar City Hospital, Biochemistry Laboratory, İstanbul, Türkiye 3Kartal Dr Lütfi Kırdar City Hospital, Department of Infectious Disease, İstanbul, Türkiye 4Kartal Dr Lütfi Kırdar City Hospital, Department of Cardiology, İstanbul, Türkiye |
Keywords: CRP, Fever, NT-proBNP, Procalcitonin, Heart failure |
Objective: We aimed to investigate the NT-proBNP levels in high fever patients without heart failure, to
contribute to the proper request and interpretation of the test.
Methods: Patients group included 31 patients who admitted with a body temperature ≥38ºC and
showed no signs of heart failure on their echocardiograms. Patients were internalized in the Infectious
Diseases Clinic. The control group included 31 healthy subjects. NT-pro-BNP, Procalcitonin (Cobas e
601 Roche Diagnostics, Germany), Complete Blood Count (Beckman Coulter LH 780, USA) and CRP
(Siemens BN II Nephelometer, Germany) levels were evaluated.
Results: Median (2.5-97.5 % percentiles) body temperature values of the patients and controls were
38.4 (38.0 - 39.8) and 36.1 (36-36.6) C° respectively (p < 0.0001). Median (2.5-97.5 % percentiles) NTproBNP
levels of the patients and control groups were; 240 (48.3- 2637) and 34.8 (5.35-86) ng/L
respectively (p < 0.0001). NT-proBNP levels correlated significantly with body temperature, CRP, and
PCT ( r=0.761, 0.726 and 0.727 respectively, all p’s < 0.0001). We observed recovery at 8 patients (at
least 48 hours without fever), and median (2.5-97.5 % percentiles) NT-proBNP levels at time of fever and
without fever were 378.3 ( 80.2- 1642) and 183 (9- 419.8) ng/L, respectively ( p=0.007). In multiple
regression analyses; body temperature, leucocyte count and PCT were found predictive for NT-proBNP
levels. (R²=0,456, F=11.987, P<0,001)
Conclusion: Despite to the normal cardiac functions, elevated NT- proBNP levels are observed in
patients with fever. This situation should be considered in the interpretation of high NT- proBNP levels.
|
|
|