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2020, Cilt 18, Sayı 2, Sayfa(lar) 101-106
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Is HbA1c a marker of urinary tract infections of diabetic patients?
Işıl ÇAKIR
Kayseri Şehir Hastanesi Hastanesi, Biyokimya, Kayseri, Türkiye
Keywords: HbA1c; type 2 diabetes mellitus; leukocyturia

Aim: The frequency and severity of urinary tract infections (UTI) in diabetic patients are increasing. HbA1c retrospectively gives important information about glycemic control. In this study it was aimed to examine the relationships between presence of microscobic leukocyturia detected in rutine urinalysis and blood glucose, HbA1c, white blood cell (WBC), mean platelet volume (MPV) and neutrophil/ lymphocyte count ratio (NLR) and to investigate the correlations between these parameters.

Material and Methods: 138 Type 2 diabetes mellitus (T2DM) patients with leukocyturia and 72 T2DM patients without leukocyturia (control group) included in the study. Patients’ simultaneous complete urinalysis, complete blood count parameters, fasting blood glucose and HbA1c levels were recorded.

Results: Mean WBC, lymphocyte and PLT levels of patients were higher, MPV was lower than control group’s. Median NLR level of patients was higher than controls. Fasting glucose and HbA1c mean levels of patients were statistically significantly higher than controls (P=0.018 ve P=0.06, respectively). Mean level of urine density of patients was higher than contol group’s mean level. Mean pH levels of patients and controls were 5.93 ± 0.62 ve 6.42 ± 0.65, respectively. The difference between both mean levels were found statistically significant (P<0.001).

Conclusion: HbA1c and inflammation markers of patient group with leukocyturia were higher than diabetics without UTI. A statistically significant positive correlation was seen between HbA1c and WBC levels. But diagnostic values of HbA1c, WBC, NLR and MPV were found relatively low in T2DM patients with leukocyturia.


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