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2020, Cilt 18, Sayı 2, Sayfa(lar) 077-084
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Osteopontin Levels in Ocular Behçet's disease: A Controlled Study
Ayça Tuzcu1, Serdal Uğurlu2, Gülnur Andican3, Yılmaz Özyazgan4, Hasan Yazıcı2
1Aydın Adnan Menderes Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın, Türkiye
2İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Romatoloji Anabilim Dalı, İstanbul, Türkiye
3İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Biyokimya Anabilim Dalı, İstanbul, Türkiye
4İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, İstanbul, Türkiye
Keywords: Autoimmunity; Behçet's disease; IL-10; IL-12; Osteopontin; SLE; Uveitis

Purpose: Osteopontin (OPN) is a cytokine involved in inflammatory and autoimmune mechanisms. In this study, we aimed to investigate OPN role in eye involvement in Behçet's disease (BD). To assess OPN in eye involvement in BD by comparing OPN and other cytokine levels both in BD and in systemic lupus erythematous (SLE), an autoimmune disease, and in healthy controls.

Materials and methods: OPN, interleukin-10 (IL-10) and interleukin-12 (IL-12) levels were measured in 22 BD patients (once during an eye attack and once when the attack subsided) as well as 18 SLE patients and 18 healthy controls.

Results: The OPN levels were increased in SLE and in active and inactive Behçet's uveitis. The IL-10 and IL-12 were significantly increased only in SLE patients.

Conclusions: Although OPN levels in BD patients were significantly higher with healthy controls, no differences in OPN levels were observed between active-inactive Behçet's uveitis or between active Behçet's uveitis and SLE. This may suggest that OPN might not be an important cytokine at least in BD eye disease.


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