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2019, Cilt 17, Sayı 1, Sayfa(lar) 048-055
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New Parameters of Coronary Artery Diseases: Oxidative Stress Markers
Uğur Erçin1, Ayşe Bilgihan2, Aycan Fahri Erkan3, Hayati Yücel4
1Halk Sağlığı Laboratuvarı, Tıbbi Biyokimya Laboratuvarı, Balıkesir, Türkiye
2Ufuk Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Ankara, Türkiye
3Ufuk Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Ankara, Türkiye
4Dr. Münif İslamoğlu Devlet Hastanesi, Acil Tıp, Kastamonu, Türkiye
Keywords: Coronary artery disease; Oxidative stress; MDA(Malondialdehyde); AOPP(Advanced Oxidation Product of Proteins)

Aim: The aim was to determine if the malondialdehyde (MDA) and advanced oxidation products of protein (AOPPs) levels, which are oxidative stress parameters, can be used to determine the degree of coronary artery disease.

Materials and Methods: The patients undergoing coronary angiography with the suspicion of coronary artery disease were divided into three groups based on the severity of disease by a stenosis scoring, Gensini scoring system. The patients with a Gensini score between 0 and 4 were assigned as Group I (control group). Those with a Gensini score between 5-35 were assigned as Group II and those having Gensini score >35 were as Group III. Plasma MDA levels were measured using a modification of the chromatographic degradation of MDA hydrazone by high performance liquid chromotagraphy, whereas plasma AOPP levels were measured spectrophotometrically.

Results: In the present study, a statistically significant difference was found between Group I and Group III in terms of plasma MDA levels, which is an indicator of stress (p=0.048). There were statistically significant differences between Group I and Group III and between Group II and Group III in terms of plasma AOPP levels (p=0.034, p=0.039, respectively). It was observed that the Gensini scores of participants had positive correlations with MDA and AOPP levels (r=0.271, p=0.021; r=0.241, p=0.041, respectively).

Conclusion: In the present study, it was determined that the severity of coronary artery disease has a relationship with AOPP and MDA levels. An increase was observed in the levels of these parameters as the severity of coronary artery disease increased.It is concluded that the AOPP and MDA levels can be used to determine the degree of coronary artery disease.


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