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2019, Cilt 17, Sayı 1, Sayfa(lar) 001-009
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The Relation Between Plasma 25-Hydroxy Vitamin D3 Levels, Disease Activity and Inflammatory Markers in Behçet Disease
Veysel Sucu1, Müberra Vardar2, Ralfi Singer2, Mustafa Durmuşcan3, Okan Dikker4
1Gümüşhane Devlet hastanesi, Tıbbi Biyokimya, Gümüşhane, Türkiye
2Okmeydanı Eğitim ve Araştırma Hastanesi, Tıbbi Biyokimya, İstanbul, Türkiye
3Adana Halk Sağlığı Laboratuvarı, Tıbbi Biyokimya, Adana, Türkiye
4Tıbbi Biyokimya Okmeydanı Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye
Keywords: Behcet Disease; 25-Hydroxyvitamin D3; Autoimmunity

Objective: Autoimmunity is an important factor in the pathogenesis of Behcet Disease emphasized in recent years In recent studies, Vitamin D has been demonstrated to play a significant role in immune system functioning. The measurement of plasma 25-hydroxyvitamin D3 levels, is accepted as a clinical indicator of vitamin D status. This study aimed to investigate plasma levels of 25-hydroxyvitamin D3 in patients with Behcet disease and to evaluate their raltionship to disease activity and inflammmatory markers.

Material and Methods: Twenty eight active Behcet Disease and fourty eight inactive Behcet Disease patients diagnosed according to the International Study Group Criteria for Behcet Disease and fourty two healthy volunteers as control group were included in this study. They were recruited from the impatient and outpatient clinics of Dermatology of Okmeydani educational and researching hospitals in the period between March 2016 and June 2016. The erythrocyte sedimentation rate (ESR) was determined according to the Westergren method and C-reactive protein (CRP) by turbidimetric method. 25-hydroxyvitamin D3 levels were determined by Liquid chromatography tandem mass spectrometry. Statistical analysis of data was performed with SPSS 17.0.1 package program.

Results: Plasma 25-hydroxyvitamin D3 levels of active, inactive patients and controls were 13,25±8,8 ng/mL, 11,06 ng/mL and 21,99±6 ng/mL respectively. In patients with Behcet’s Disease, 25- hydroxyvitamin D3 values were significantly lower than those of the healthy controls (p<0,001). There were no significant differences between active Behcet Disease and inactive Behcet Disease groups regarding 25-hydroxyvitamin D3 (p>0,05). Significant negative correlations of plasma 25-hydroxyvitamin D3 levels with ESR and CRP were found in the inactive Behcet Diseases ( CRP r= -0,426 p=0,007, ESR r= -0,340 p=0,034).

Conclusion: As the result of this study, plasma levels of 25-hydroxyvitamin D3 were significantly low in Behcet Disease patients compared to control groups. On account of our study suggests that deficiency of 25-hydroxyvitamin D3 may be predisposition factor for Behcet Disease. However, associations were not found between 25-hydroxyvitamin D3 levels and disease activity as well as ESR and CRP in the Behcet Disease patients.


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