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2018, Cilt 16, Sayı 2, Sayfa(lar) 127-134
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Metabolomics Approach in Vitamin D
Bilge Karatoy Erdem, Halide Akbas
Akdeniz Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Antalya, Türkiye
Keywords: Vitamine D, 25(OH)D, 1,25(OH)2D3, 3-epi-25(OH)D, 24,25(OH)2D3 vitamin D, 25(OH)D, 1,25(OH)2D3, 3-epi-25(OH)D, 24,25(OH)2D3

Vitamin D is a molecule, now seen as a hormone, it plays an important role in bone health, it is also associated with many diseases, such as diabetes, cancer and cardiovascular problems. 25- hydroxyvitamin D [25(OH)D] is used to estimate vitamin D status because its long half-life. However, to understand the pathophysiological role of vitamin D metabolites on various diseases, we need to evaluate all relevant metabolome. For this reason, a metabolomic panel is required to evaluate the vitamin D status that measurement of 25 (OH) D and other vitamin D biomarkers, e.g., 1α,25 (OH)2 D3 , 3-epi-25 (OH) D, 24,25 (OH)2 D3, vitamin D binding protein (DBP), free/bioavailable 25 (OH) D and parathyroid hormone. Mass spectrometers are promising for comprehensive analysis of vitamin D metabolites in the future.

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