Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim  
2018, Cilt 16, Sayı 2, Sayfa(lar) 101-108
[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Serum Adiponectin, ICAM-1 and VCAM-1 Concentrations in End-Stage Renal Disease
Yeşim Güvenç1, Mustafa Serteser2, Ece Onur1, Fatma Taneli1, Soner Cander3, Tülay Köken4
1Celal Bayar Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya, Manisa, Türkiye
2Acıbadem Mehmet Ali Aydınlar Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya , İstanbul, Türkiye
3Afyon Devlet Hastanesi, İç Hastalıkları, Afyon, Türkiye
4Afyon Kocatepe Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya, Afyon, Türkiye
Keywords: adiponectin; ICAM-1; VCAM-1; eGFR ; end-stage renal disease

Purpose: End-stage renal disease; is a disease characterized by loss of renal function where inflammation is involved in its pathogenesis. Adiponectin is an anti-inflammatory protein secreted from the adipose tissue. ICAM-1 and VCAM-1 are vascular adhesion molecules that play a role in regulation of inflammation. The aim of the present study is to investigate adiponectin, ICAM-1 and VCAM-1 as clinical biomarkers of inflammation in patients with end-stage renal disease.

Materials and methods: The study groups were defined as; Group 1: (n=31) end-stage renal disease patients (eGFR<15) with hemodialysis; Group 2: (n=33), healthy subjects (eGFR≥90). We assessed serum adiponectin, VCAM-1 and ICAM-1 concentrations by ELISA methods. Chi-square test, students-t test, co-variance analysis, pearson correlation test were used for statistical analysis.

Results: Serum adiponectin, VCAM-1 and ICAM-1 levels were significantly higher in patients than the control group (p=0.001, p=0.001, p=0.001, respectively). Adiponectin was directly correlated with VCAM-1 (r=0.615, p<0.001) and ICAM-1 levels (r=0.476, p< 0.001). eGFR was inversely correlated with adiponectin (r=-0.637, p<0.001), ICAM-(r=-0.598, p<0.001), VCAM-1 levels (r=-0.846, p<0.001).

Conclusion: Adiponectin, VCAM-1 and ICAM-1 concentrations were significantly increased in patients with end-stage renal disease. We observed that as the eGFR are decreased the adiponectin, VCAM-1 and ICAM-1 concentrations were increased. Elevated levels of adiponectin, VCAM-1 and ICAM-1 may result due to inflammatory response, impaired renal clearance and metabolic disturbance. We suggest that further studies including greater number of patients are necessary to confirm that adiponectin, VCAM-1 and ICAM-1 can be used as biomarkers of inflammatory response in end-stage renal disease patients.


[ Türkçe Özet ] [ PDF ] [ Benzer Makaleler ]
Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | İletişim