2018, Cilt 16, Sayı 2, Sayfa(lar) 072-076 |
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Are the Flags Sufficient in the Detection of Exceeding Linearity in Photometric Tests? |
Esin Çalcı1, Fatma Meriç Yılmaz2, Turan Turhan1 |
1Ankara Numune EAH, Tıbbi Biyokimya, Ankara, Türkiye 2Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Biyokimya Anabilim dalı, Ankara, Türkiye |
Keywords: Dilution, Linearity, Photometry, Flag |
Purpose:One of the important problems encountered in the confirmation of the results in photometric
tests is the detection of samples exceeding linearity. In situations where linearity is exceeded, especially
enzyme levels may give different results than the true value. If this can not be detected during the
approval phase, serious problems can arise in the diagnosis and treatment of the patients. A number of
flags are defined for situations where the results exceed the linearity values. In the presence of these
flags, it is recommended that samples be sent to dilution. In this study, it is aimed to examine the flags
defined for the Roche Moduler P autoanalyzer.
Materials and Methods: Our hospital Biochemistry Laboratory samples which were diluted between
February and October 2013 was included study. If there are flags, it is recorded. If the difference
between the values before and after dilution exceeds the CLIA 88 limits, for example, the linearity value
is assumed to be exceeded.
Results: A total of 479 parameters were diluted and there were flags in 428 parameters. No flags were
detected in 51 parameters. Significant differences after the dilution procedure have been observed in
197 samples. It was observed that 9,1 % of the samples exceeding the linearity had no flag.
Conclusion: The study concluded that each sample giving a warning sign should be sent to the
dilution, but the clinical fit should be assessed absolutely even in the test without the flag.
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