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2018, Cilt 16, Sayı 1, Sayfa(lar) 053-062
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Role of Vascular Endothelial Growth Factor in Physiological and Pathological Angiogenesis
Pervin Vural
İstanbul Tıp Fakültesi, Tıbbi Biyokimya AD, İstanbul, Türkiye
Keywords: VEGF, VEGF receptor, angiogenesis, cancer

Angiogenesis is a biological process involving the formation of new blood vessels from existing vessels. Vascular endothelial growth factor (VEGF) has an important role in the angiogenesis. The VEGF family consists of seven members. VEGF-A, VEGF-B, VEGF-C, VEGF-D and PlGF (placental growth factor) are found in mammals. VEGF-E is found in parapox viruses, and VEGF-F, also known as svVEGF, is found in snake venom. These family members are interact with VEGFR-1, VEGFR-2, VEGFR-3 and neuropilin (NP- 1 and NP-2) receptors. VEGF and its receptors expression increased in many cancers. VEGF-A is implicated in tumor growth and metastasis via blood vessels while VEGF-C and VEGF-D, involved in lymphangiogenesis, favour metastasis to lymp vessels. Because of its important role in malignant angiogenesis, VEGF family and receptors are the preferential target of a new variety of therapeutics called angiogenesis inhibitors. Recently many anti-VEGF/VEGFR drugs have been developed and approved by the Food and Drug Administration (FDA) for use in the routine treatment of various cancers.

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