2016, Cilt 14, Sayı 3, Sayfa(lar) 172-180 |
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Comparison of Neutrophil/Lymphocyte Ratio and Red Blood Cell Distribution Width with Cardiac Markers in Acute Coronary Syndrome |
Saadet Çelik1, Nezaket Eren1, Arzu Er2, Fatma Turgay1, Şebnem Ciğerli1, Kadriye Kılıçkesmez2, Erdinç Serin1 |
1Sağlık Bilimleri Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi, Klinik Biyokimya, İstanbul, Türkiye 2Sağlık Bilimleri Şişli Hamidiye Etfal Eğitim ve Araştırma Hasta, Kardiyoloji Kliniği, İstanbul, Türkiye |
Keywords: Acute coronary syndrome (ACS), Neutrophil / lymphocyte ratio (NLR), Red cell distribution width (RDW), ST elevation myocardial infarction (STEMI), Unstable angina pectoris (USAP), NSTEMI (Non ST segment elevation myocardial infarction) |
Objective: Acute coronary syndrome (ACS) is a group of symptoms for acute myocardial ischemia. The
RDW (red cell distribution width), recently described as a novel risk marker, has been associated with an
increased risk of cardiovascular events and routinely reported as part of the complete blood count. We
assessed the relationship of hematologic parameters (RDW and NLR) with cardiac markers (Troponin I
(TnI), CK-MB) in patients admitted with ACS.
Material and Methods: In this study, 228 patients with acute coronary syndrome were retrospectively
evaluated. For all patients, a baseline blood sample was collected for routine hematological testing. The
patients were diagnosed as Non ST elevation myocardial infarction (NSTEMI), ST elevation myocardial
infarction (STEMI) or unstable angina (USAP) based on the elevation of cardiac TnI levels in the first and
sixth hours of admission. SPSS version 15.0 program was used for statistical analysis.
Results: There was no difference in the levels of RDW in NSTEMI and USAP groups (p=0.154). In the
ACS subtypes groups, NLR showed a negative correlation with EF (p<0.001) and significant positive
correlation with the first hour levels of CK-MB and TnI (p<0.001). It was also found that NLR showed
positive correlation with STEMI groups (p<0.001).
Conclusion: It was determined that there was no statistically significant difference between RDW and
ACS subtypes. Finding NLR levels being significantly high in STEMI group of ACS patients revealed out
that NLR can be a useful marker in ACS. We suggest that these findings should be evaluated and
supported with prospective studies.
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