2014, Cilt 12, Sayı 1, Sayfa(lar) 045-056 |
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Mikro RNA and Cancer |
Barbaros Şahin Karagün, Bülent Antmen, İlgen Şaşmaz, Yurdanur Kılınç |
Çukurova Üniversitesi Tıp Fakültesi, Çocuk Hematoloji AD, Adana, Türkiye |
Keywords: MikroRNA; cancer; RNA interference; RNA-induced silencing complex |
Mikro-RNAs are functional, non-protein coding RNA molecules and their transcriptions provided by
intron or exon regions of the genome and non-protein coding regions of RNA genes. Mikro-RNAs inhibit
translation of protein and / or cause destruction of mRNA. Most of studies have demonstrated that many
of these small molecules have critical importance in many important cellular events such as
hematopoiesis, differentiation, proliferation and apoptosis. The role of mikro-RNAs in malign diseases
have become the subject of research increasingly. Mikro-RNAs play a role in different events such as cell
growth, differentiation, proliferation and death by suppressing one or more target gene. More than 50%
of miRNA genes are located on the genome which has associated with cancer. A large number of
experimental studies show that miRNAs may have generate a new class of oncogenes or tumor
suppressor gene. MiRNAs are thought to be identified at a different level of expression in normal and
pathological tissues can be determined between the miRNAs that are effective diagnosis and treatment
of human cancers.
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