2014, Cilt 12, Sayı 1, Sayfa(lar) 021-029 |
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Fetuin-A and Osteopontin in the Etiopathogenesis of Nephrolithiasis |
Fatih Yaman1, Hülya Aybek2, Zafer Aybek3 |
1Şebinkarahisar Devlet Hastanesi, Tıbbi Biyokimya, Giresun, Türkiye 2Pamukkale Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya, Denizli, Türkiye 3Pamukkale Üniversitesi Tıp Fakültesi, Üroloji, Denizli, Türkiye |
Keywords: urine; osteopontin; fetuin |
Objective: In our study we aimed to investigate the role of fetuin-A, a systemic calcification inhibitor,
and osteopontin, which plays an important role in calcification processes, in the pathogenesis of urinary
tract stone disease.
Materials and Methods: Our study group included 111 patients diagnosed with nephrolithiasis and 66
healty volunteers. Serum and urine calcium, phosphorus, magnesium, uric acid, creatinine levels and urine oxalate, citrate, fetuin-A, osteopontin and GAG levels are determined in all individuals. Stone
analysis has been performed, if available.
Results: Urine osteopontin levels in the patient group has been found to be significantly lower
compared with control group. There was no difference between control and patient group in terms of
urine fetuin-A levels. In patient group urine oxalate and calcium levels were higher and urine citrate
levels and urine GAG/creatinine ratio was lower compared with control group. Although there was no
significant correlation between fetuin-A and urine calcium, phosphorus, magnesium, uric acid, oxalate,
citrate, GAG levels, there was a weak statistically significant positive relationship between urine
osteopontin and magnesium levels.
Conclusion: New studies are needed that use of osteopontin and fetuin A in diagnosis and follow up of
nephrolithiasis
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