2014, Cilt 12, Sayı 1, Sayfa(lar) 009-014 |
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The Effect of Exercise on Oxidative Stress Parameters in Lung Tissue of Rat with Hyperthyroidism |
Elvin Aliyev1, Abdulkadir Yıldırım1, Serap Yıldırım2, Engin Şebin1 |
1Atatürk Üniversitesi Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Erzurum, Türkiye 2Atatürk Üniversitesi Tıp Fakültesi, Tıbbi Fizyoloji Anabilim Dalı, Erzurum, Türkiye |
Keywords: Exercise; hyperthyroidism; malondialdehyde; myeloperoxidase; nitric oxide |
Objective: The aim of this study is to investigate whether there is any protective effect of a regular
endurance exercise on the L-Thyroxine-induced oxidative stress in lung tissue of rats.
Materials and methods: Twenty-three male Sprague Dawley rats were divided into four groups:
Control, hyperthyroidism, exercise, and hyperthyroidism plus exercise. Hyperthyroidism was induced in rats by injecting subcutaneous 250 μg L-Thyroxine / kg body weight/day. Endurance training consisted
of treadmill running at a speed of 23 m/minute, 45 minute /day, 5 days a week for 8 weeks. The levels
of malondialdehyde (MDA) and nitric oxide ( NO) and myeloperoxidase (MPO) activities were measured
in the lung homogenates.
Results: When compared to the control group, the highest MDA and the lowest NO levels were
observed in the hyperthyroidism group. In addition, the highest MPO activity was measured in the
exercise group when compared with control rats. However, the differences between groups were not
statistically significant for all parameters.
Conclusion: In the experiment of hyperthyroidism of training rat model; the results indicates that on
the statistical value there is no significant change which is examined of either endurance training or
injecting 250 μg L-Thyroxine / kg body weight parameters of MDA, NO, and MPO in lung tissue of rats
with hyperthyroidism.
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