EISSN: 2980-0749
  Ana Sayfa | Amaç ve Kapsam | Dergi Hakkında | İçindekiler | Arşiv | Yayın Arama | Yazarlara Bilgi | Etik İlkeler | İletişim  
2010, Cilt 8, Sayı 3, Sayfa(lar) 111-116
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Comparison of MDRD Formula with extended-MDRD Which Were Used to Calculate GFR
Metin Demir, Özgür Aslan, Ayşenur Atay, Mehmet Hicri Köseoğlu, Nejla Barış, Serap Çuhadar
İzmir Atatürk Eğitim ve Araştırma Hastanesi II. Biyokimya Kliniği, İzmir
Keywords: Glomeruler Filtration Rate (GFR), MDRD, extended MDRD

Objective: Glomerular Filtration Rate (GFR) is the best indicator for the reflecting of kidney function in health and disease. In this study we compared -Glomerular Filtration Rate (GFR) calculation formulas – 4 variables Modification of Renal Disease (MDRD) formula with the 6 variables extended-MDRD in which BUN and albumin results also used.

Materials and Methods: 187 patients data were examined for this study. Patients GFR were calculated using Modification of Diet in Renal Disease (MDRD) method and four groups were formed. The level of GFR was determined according to the ex-MDRD formula in all groups and One-Sample Kolmogorov- Smirnov test and Pearson correlation analysis were performed. p <0.05 was considered statistically significant.

Results: Mean value of patients GFR were 30.81±18.46 mL/dk/1.73 m2 with MDRD equation, 30.95±18.91 mL/dk/1.73 m2 with ex-MDRD equation. When serum creatinin concentration increased GFR levels which were calculated from MDRD formula were decreased and there was a positive correlation between the two groups (r = 0.994, p <0.001).

Conclusion: Two formulas can be used for MDRD equation in order to evaluate GFR. Ex-MDRD method is different from MDRD method as BUN and albumin results are also used. In our study correlation between both methods was higher. According to this, MDRD results can be used instead of 6 variables ex-MDRD in order to obtain GFR results. GFR can be calculated with the data of age, gender, ethnicity and the value of serum creatinin in order to using MDRD formula so that serum BUN and albumin results are not necessary.


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