2010, Cilt 8, Sayı 2, Sayfa(lar) 075-089 |
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Asymmetric Dimethylarginine and it's Clinical Significance |
Özben Özden Işıklar1, Işıl Mutaf2 |
1Nenehatun Kadın Doğum Hastanesi, Tıbbi Biyokimya, Erzurum 2Ege Üniversitesi Tıp Fakültesi, Klinik Biyokimya, İzmir |
Keywords: Asymmetric dimethylarginine, nitric oksid, endotel disfunction, cardiovascular risk factors |
Asymmetric dimethylarginine (ADMA) is an amino acid that looks like arginine and exists in plasma,
urine and tissues. ADMA occurs naturally by methylation of arginine remnants in proteins and the
studies about it increases every day. ADMA, as a major inhibitor of nitric oxide sentase is accepted as
cardiovascular risk factor. In this review, the knowledge about metabolism, the relation of ADMA with
several patologies, primarily endothelial dysfunction and the measurement methods were overviewed
and the results of clinical and experimental studies were discussed.
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