Transforming growth factor-β(TGFβ) has a crucial role in tissue homeostatsis and disruption of TGFβ signaling pathway has been implicated in cancer. As a potential inhibitor of epithelial cell proliferation and inflammatory response, together with a proapoptotic effect, TGFβ is a tumor suppressor. Tumor cells evade the antitumoral effect of TGFβ, either by acquiring mutations in sitoplasmic branch elements that blunt TGFβ signaling or by selectively preventing the sitostatic responses to TGFβ (nuclear branch). During tumor progression, TGFβ not only losses the antiproliferative response but can also become an oncogenic factor. This review is an overview of the mechanisms leading to impairment of tumor suppressive function of TGFβ in cancer.